The monoamine theory of depression as a target to effective pharmacotherapy

Abstract Depression is one of the greatest current mental disorders. Depressive disorder may affect everyone and it causes difficulties in social functioning lead to death via suicide. a serious problem because number its cases increasing, especially after pandemic COVID-19. The oldest most approved theory which explains mechanism depression’s development monoamine hypothesis. Effectiveness antidepressant drugs based on this theory. It assumes that typical symptoms depression are results changed concentration monoamines or incorrect monoaminergic transmission. aim article present have influence level biogenic amines used treatment depressive Some those first choice cure disease. In spite adverse effects often delayed onset action pharmacotherapy, still line depression.